Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling

► PAK4 nuclear export is mediated by CRM-1-dependent pathway. ► PAK4 interacts with and phosphorylates β-catenin on Ser675. ► PAK4 phosphorylation of β-catenin on Ser675 promotes its transcriptional activity. ► Nuclear import of PAK4 accompanies with the nuclear import of β-catenin. ► PAK4 associates with the TCF/LEF transcriptional complex.