A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity

► p62 is localized to the mitochondria where it plays a physiological role. ► p62 affects both mitochondrial morphology and function. ► p62 is involved in maintenance of mitochondrial genome stability. ► p62 regulates the import of TFAM to mitochondria. ► mtDNA biogenesis is affected by p62 beyond regulation provided by Δψm.