Histone deacetylase inhibitor induction of epithelial-mesenchymal transitions via up-regulation of Snail facilitates cancer progression

► We found that HDACIs induced EMT in cancer cells to facilitate cancer progression. ► In CNE2, LoVo, HepG2, HDACIs up-regulate Snail and Vimentin and down-regulate E-cadherin. ► We provided that Snail plays an important role in the HDACI-induced EMT. ► It shows that more attention should be paid to the cancer treatment using HDACIs.