Estrogen-induced upregulation of Sftpb requires transcriptional control of neuregulin receptor ErbB4 in mouse lung type II epithelial cells

► We demonstrated that estrogen and NRG treatment stimulated Sftpb expression. ► The expression of ERβ and ErbB4 stimulated Sftpb promoter activity. ► Estrogen induced nuclear translocation of ErbB4. ► Estrogen effects on Sftpb expression require interaction of ERβ and ErbB4. ► Stimulatory effects on Sftpb might be under transcriptional control of ErbB4.