TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

► TRIM8 interacted with Hsp90β, which selectively downregulates transcription of Nanog. ► Knock-down of TRIM8 increased transcription of Nanog. ► TRIM8 may modulate translocation of STAT3 into the nucleus through Hsp90β.