Protein kinase C α regulates nuclear pri-microRNA 15a release as part of endothelin signaling

► PKC α translocates into the nucleus as part of the NF-κB transcription complex. ► PKC α binds to pri-miRNA 15a, prevents its nuclear release and maturation to miRNA. ► Levels of PKC α and miRNA 15a are inversely related in different human cell lines. ► This signalling occurs via endothelin-1 binding to its surface receptors. ► miRNA 15a expression is dependent on expression of both endothelin receptors.