HIV-1 Tat binds to SH3 domains: Cellular and viral outcome of Tat/Grb2 interaction

► The SH3 domain of Grb2 interacts with HIV-1 Tat protein. ► Tat/Grb2 interaction affects cellular signaling pathways and viral functions. ► It impairs IGF-1R/ERK activation and enhances PKA/Raf inhibitory cascade in LN229. ► It inhibits viral replication in HIV-infected human primary microglia.