Proteolytic action of kallikrein-related peptidase 7 produces unique active matrix metalloproteinase-9 lacking the C-terminal hemopexin domains

► KLK7 and MMP-9 are expressed in pancreatic, breast, cervical, and ovarian cancers. ► KLK7 cleaves proMMP-9 to produce a unique truncated, active gelatinase. ► Active MMP-9 lacking the hemopexin domains may have altered substrate specificities.