Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression

► Cyclosporin A impairs phosporylation of Akt and FAK. ► Akt signaling regulates motility and invasiveness of malignant glioblastoma cells. ► PI-3K/Akt signaling regulates subcellular localisation of MT1-MMP. ► MT1-MMP locally influences MMP-2 activity and facilitates formation of invadopodia. ► Expression of MMP-2 and MT1-MMP is regulated in an Akt-dependent manner.