Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells

► Camptothecin and doxorubicin stimulated de novo synthesis ceramide pathway. ► Produced ceramide activated JNK/ATF-2 pathway. ► JNK/ATF-2 decreased TSP-1 expression and induced apoptosis.