Ataxin-1 occupies the promoter region of E-cadherin in vivo and activates CtBP2-repressed promoter

► Ataxin-1 interacts and colocalizes with CtBP2. ► Ataxin-1 occupies the endogenous E-cadherin promoter in vivo. ► Overexpression of ataxin-1 enhances E-cadherin expression at the protein and mRNA levels. ► Ataxin-1 activates the E-cadherin gene promoter in a CtBP2-dependent manner.