ESeroS-GS modulates lipopolysaccharide-induced macrophage activation by impairing the assembly of TLR-4 complexes in lipid rafts

► ESeroS-GS is a novel antioxidant derived from vitamin E. ► LPS activates macrophages. ► ESeroS-GS inhibits the assembly of TLR-4 complex and regulates macrophage activation in vitro and in vivo through lipid raft dependent mechanism.