Calcium signaling in osteoclasts

► Calcium signaling plays a significant role in the process of osteoclastogenesis. ► The RANKL receptor utilizes calcium signaling and activation of NFAT to drive differentiation of osteoclasts. ► Recent studies demonstrate that a key component of osteoclast calcium signaling involves influx through plasma membrane channels, including members of the TRP channel superfamily, as well as store-operated channels.