PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway

► PKC-ι co-localizes and directly associates with Bad in glioma cells. ► PKC-ι directly phosphorylates Bad at Ser-112, Ser-136 and Ser-155. ► Knockdown of PKC-ι leads to reduction in Bad phosphorylation. ► PI (3)-kinase and PDK1 inhibition blocks PKC-ι activity. ► PI (3)-kinase/PDK1/PKC-ι/Bad cell survival pathway in glioblastoma