Model membranes to shed light on the biochemical and physical properties of ezrin/radixin/moesin

► Biological importance of ERM in physiological and pathological processes. ► Biochemical consideration of ERM activation at the plasma membrane. ► ERM/membrane interaction and activation mechanism analysis using model membranes. ► Formation and intriguing roles of ezrin oligomers. ► ERM/actin interaction using supported lipid bilayers as membrane mimicking system.