Novel bioactive glycerol-based lysophospholipids: New data - New insight into their function

► The review is devoted to novel bioactive lysophospholipids: LPI, LPE, LPS, LPG, LPC. ► We summarize their in vivo distribution and biosynthesis pathways. ► Those LPLs regulate fundamental cellular functions by modulating multiple targets. ► They alter the structure and fluidity of lipid rafts. ► We comprehend the progress in deorphanizing GPCRs for LPC, LPS, LPI, LPG and LPE.