Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma

► The expression of aggrecanases in normal and cancerous larynx was investigated. ► ADAMTS-4/aggrecanase-1 predominated in normal larynx. ► ADAMTS-5/aggrecanase-2 was the main aggrecanase in laryngeal carcinoma. ► Carcinoma cells highly expressed ADAMTS-5/aggrecanase-2, but not ADAMTS-4/aggrecanase-1. ► ADAMTS-5/aggrecanase-2 could be a potential target for laryngeal carcinoma treatment.