IQ-motif peptides as novel anti-microbial agents

► Some IQ-motif peptides derived from IQGAP2 and IQGAP3 have antimicrobial activity. ► In general, these peptides have low haemolytic activity. ► Those peptides with antimicrobial activity tend to bind to LPS. ► Some of the peptides permeabilise the bacterial membrane. ► IQ-motifs may provide a rich source for the design of novel antimicrobial peptides.