Caveolae and non-caveolae lipid raft microdomains of human umbilical vein endothelial cells contain utrophin-associated protein complexes

► Utrophin associated protein complexes in caveolae and non-caveolae lipid rafts domains of HUVEC. ► eNOS is present in both complexes. ► Mechanical stimulus releases eNOS from the complexes and increases its active form. ► Utrophin associated protein complexes control eNOS activity.