LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA1/Egr-1 axis

► LPA induces p42/44 MAPK activation in MG-63 cells via LPA1-LPA3 receptor. ► Gαi-dependent activation through the Src family of tyrosine kinases induces functional Egr-1 expression. ► LPA-induced Egr-1 upregulation was accompanied by a time-dependent decrease of periostin. ► Silencing of LPA1 and/or Egr-1 in MG-63 cells reversed LPA-mediated suppression of periostin.