Identifying three-way DNA junction-specific small-molecules

► Identification of highly selective ligands for three-way DNA junctions (TWJ). ► Evaluation of the affinity and selectivity of the candidates for TWJ. ► Calibration of biophysical assays with a known non-specific DNA binder (TMPyP4). ► Synthesis of a small series of triazacyclononane (TACN) derivatives. ► Identification of the TWJ-affinic and -selective TACN-Q.