DNA compaction by mononuclear platinum cancer drug cisplatin and the trisplatinum anticancer agent BBR3464: Differences and similarities

► DNA compaction induced by BBR3464, at ri 0.03, is more severe than that induced by cisplatin, at ri 1.5. ► BBR3464 and cisplatin both can form DNA loop structures as a result of long-range DNA cross-links. ► The trinuclear BBR3464 forms macroloops and microloops both, while the mononuclear cisplatin forms primarily microloops.