Antiarthritic and antiinflammatory propensity of 4-methylesculetin, a coumarin derivative

► First report on the antiarthritic propensity of 4-methylesculetin. ► 4-Methylesculetin prevents cartilage and bone degeneration. ► 4-Methylesculetin alleviate arthritis induced oxidative stress in liver and spleen. ► 4-Methylesculetin quenches arthritis induced inflammatory response. ► Treatment with 4-methylesculetin restores joint homeostasis in arthritic animals.