SCN1AIVS5-91G>A polymorphism is associated with susceptibility to epilepsy but not with drug responsiveness

► Highly significant association of SCN1A IVS5-91G>A (rs3812718) with seizure susceptibility. ► No Influence of SCN1A IVS5-91G>A (rs3812718) with resistance to mono/multidrug therapy. ► SCN1A IVS5-91G>A gene involved in epilepsy pathophysiology rather than pharmacotherapy.