Preferential recognition of catechol-estrogen modified DNA by circulating autoantibodies in cancer patients

► The mechanism behind the generation of circulating antibodies in cancer can be explained. ► Role of catecholestrogens in the etiopathogenesis of different types of cancer has been evaluated. ► Anti-4-OHE2-NO-DNA antibodies in cancer patient's sera have prognostic significance. ► We have shown the combined effect of oxidative stress and estrogens in causing DNA damage making it immunogenic.