Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance

► Adipose tissue is a remarkably active organ that may act as a trigger of insulin resistance or type 2 diabetes. ► Lipid peroxidation within fat tissue generates by-products that modulate adipogenic differentiation of precursor cells. ► Oxysterols and 4-hydroxynonenal may detrimentally affect adipocyte function and systemic insulin status.