Nrf2-keap1 system versus NF-κB: The good and the evil in chronic kidney disease?

► Nrf2 modulates the anti-inflammatory cascade through the inhibition of NF-κB. ► Regulates cellular antioxidant responses. ► Activators of the Keap1-Nrf2 system are of interest in the CKD. ► Some substances are capable of inducing Nrf2.