Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway

► FTY inhibits mural cells angiogenesis through S1PR1 and S1PR3. ► FTY downregulates S1PR1 and S1PR3 expression level on VSMCs. ► S1PR1 mainly mediates PDGF-B-induced VSMC growth. ► S1PR3 mainly mediates PDGF-B chemotactic signal.