The hUPF1-NMD factor controls the cellular transcript levels of different genes of complex I of the respiratory chain

► hUPF1/hUPF2 knockdown impact on splicing isoforms of complex I genes is described. ► hUPF1/hUPF2 knockdown affected the level of different PTC-containing isoforms. ► hUPF1 knockdown affected also the level of some complex I isoforms with no PTC. ► The hUPF1 factor shows a specific role in the splicing control of complex I genes.