Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): Distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells

► CLUSTER analysis was performed on H3Ac/H3K4me/H3K9me ChIP-chip data. ► It shows mRNA expression directly correlates with H3Ac/H3K4me levels. ► H3K9me levels show inverse correlation under hyperglycemia/hyperinsulinemia. ► Increased promoter occupancy of H3Ac/H3K4me and decreased H3K9me on active genes. ► Presence of crosstalk between H3Ac and H3K4me under these conditions.