A dietary colorant crocin mitigates arthritis and associated secondary complications by modulating cartilage deteriorating enzymes, inflammatory mediators and antioxidant status

► First report on the antiarthritic efficacy of Crocin, a dietary colorant. ► Crocin mitigates arthritis induced oxidative stress in Liver and Spleen. ► Crocin inhibits cartilage and bone degeneration. ► Crocin suppresses arthritis induced inflammatory response. ► Crocin treatment restores the joint homeostasis in arthritic animals.