Impaired redox signaling and mitochondrial uncoupling contributes vascular inflammation and cardiac dysfunction in type 1 diabetes: Protective role of arjunolic acid

► Cardiovascular dysfunction is established at the early stage of type 1 diabetes. ► Antidiabetic and antioxidant role of arjunolic acid (AA) is well established. ► Hyperglycemia caused oxidative stress, vascular inflammation and cell death. ► AA reduced oxidative stress, hyperglycemia and cardiovascular dysfunction. ► AA may act as beneficial agent in diabetic cardiovascular pathophysiology.