Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium

► Palmitate (PA) induced inflammation-related insulin resistance in the endothelium. ► Pretreatment of luteolin effectively reversed the effects of PA. ► Luteolin inhibited inflammatory response and improved the insulin sensitivity. ► Its action depended on an IKKβ/IRS-1/Akt/eNOS pathway.