کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10814954 | 1058437 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system
ترجمه فارسی عنوان
مسیرهای سیگنالینگ بر سر راه تعیین سرنوشت سلول های خاردار عصبی به خطوط گلیال در سیستم عصبی محیطی در حال توسعه
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Fate determination of neural crest cells is an essential step for the development of different crest cell derivatives. Peripheral glia development is marked by the choice of the neural crest cells to differentiate along glial lineages. The molecular mechanism underlying fate acquisition is poorly understood. However, recent advances have identified different transcription factors and genes required for the complex instructive signaling process that comprise both local environmental and cell intrinsic cues. Among others, at least the roles of Sox10, Notch, and neuregulin 1 have been documented in both in vivo and in vitro models. Cooperative interactions of such factors appear to be necessary for the switch from multipotent neural crest cells to glial lineage precursors in the peripheral nervous system. This review summarizes recent advances in the understanding of fate determination of neural crest cells into different glia subtypes, together with the potential implications in regenerative medicine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 26, Issue 4, April 2014, Pages 673-682
Journal: Cellular Signalling - Volume 26, Issue 4, April 2014, Pages 673-682
نویسندگان
Maulilio John Kipanyula, Wahabu Hamisi Kimaro, Faustin N. Yepnjio, Yousef H. Aldebasi, Mohammed Farahna, Armel Herve Nwabo Kamdje, Eltuhami M. Abdel-Magied, Paul Faustin Seke Etet,