LIM-domain proteins in transforming growth factor β-induced epithelial-to-mesenchymal transition and myofibroblast differentiation

► LIM-domain proteins regulate cell differentiation and phenotype. ► Their expression is regulated by extracellular signals, such as TGFb. ► LIM-only proteins are present in cancer-associated fibroblasts and fibrotic diseases. ► They may pose as relevant targets for disease intervention.