New advances on the functional cross-talk between insulin-like growth factor-I and estrogen signaling in cancer

► The IGF system is involved in the development of diverse types of cancer. ► Estrogens play a main role in the progression of breast and endometrial tumors. ► ERα, ERβ and GPER mediate the estrogen signaling. ► A cross talk between IGF-I and estrogens contribute to cancer progression. ► Co-targeting estrogen and IGF-I signaling may improve anticancer strategies.