A MicroRNA, mir133b, suppresses melanopsin expression mediated by failure dopaminergic amacrine cells in RCS rats

► The melanopsin expression is decreased in RCS rats. ► The numbers of mRGCs don't change. ► Disrupted DA ACs cause a great affection to melanopsin expression. ► The overexpressed mir133b may involve in collapse of DA ACs. ► Interfered mir-133b restores DA ACs' functions and melanopsin expression level.