The Not3/5 subunit of the Ccr4-Not complex: A central regulator of gene expression that integrates signals between the cytoplasm and the nucleus in eukaryotic cells

► Not2 and 3/5 form a functional module of the conserved Ccr4-Not complex. ► In the nucleus it associates with promoters and with specific transcription factors. ► In the cytoplasm it is associated with translating ribosomes. ► In the cytoplasm it also contributes to regulate mRNA deadenylation. ► Its dual position allows integration of signals between cytoplasm and nucleus.