p130Cas: A key signalling node in health and disease

► p130Cas is a ubiquitously expressed adaptor protein. ► p130Cas is phosphorylated in response to integrin, RTK and GPCR signalling. ► p130Cas-mediated recruitment and activation of GEFs is critical for cell motility. ► Expression of p130Cas is essential for the development of the cardiovascular system. ► Aberrant p130Cas signalling contributes to the development of several human cancers.