The dioxin receptor controls β1 integrin activation in fibroblasts through a Cbp-Csk-Src pathway

► A novel mechanism for the control of cell adhesion and migration by AhR is proposed. ► AhR modulates β1 integrin activation by inside-out control of the Cbp/Csk-Src pathway. ► AhR also regulates β1 integrin activation by outside-in signaling from fibronectin. ► AhR expression should be considered in pathologies involving β1 integrin activation.