Inhibition of platelet-derived growth factor receptor tyrosine kinase and downstream signaling pathways by Compound C

► Compound C is an inhibitor of AMPK. ► Compound C inhibits cell proliferation by inducing Go/G1 cell cycle arrest. ► Compound C inhibits the phosphorylation of PDGFRβ but not EGFR and IGF1R. ► Compound C inhibits the in vitro tyrosine kinase activity of PDGFRβ. ► The inhibitory effect of Compound C on PDGFRβ is independent of AMPK.