Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-kB in human lung cancer A549 cells

► RAGE and retinol are involved in lung cancer. ► Retinol activated ROS production, p38, NF-kB and downregulated RAGE ► RAGE is inhibited by redox-dependent p38 and NF-kB activation in lung cancer cells. ► Evidences a redox mechanism of RAGE regulation in lung cancer cells by vitamin A