کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10816288 | 1058555 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of Ca2Â + in proteolysis-inducing factor (PIF)-induced atrophy of skeletal muscle
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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![عکس صفحه اول مقاله: Role of Ca2Â + in proteolysis-inducing factor (PIF)-induced atrophy of skeletal muscle Role of Ca2Â + in proteolysis-inducing factor (PIF)-induced atrophy of skeletal muscle](/preview/png/10816288.png)
چکیده انگلیسی
⺠PIF induced a rapid rise of Ca2 +i, in C2C12 murine myoblasts, which was completely attenuated by an anti-receptor antibody, or peptides representing 20 mers of the N-terminus of the PIF receptor. ⺠Other agents catabolic for skeletal muscle including angiotensin II (AngII) tumour necrosis factor-α (TNF-α) and lipopolysaccharide (LPS) also induced a rise in Ca2 +i, but this was not attenuated by anti-PIF-receptor antibody. ⺠The rise in Ca2 +i induced by PIF and AngII was completely attenuated by the Zn2 + chelator D-myo-inositol-1,2,6-triphosphate, and this was reversed by administration of exogenous Zn2 +. ⺠This rise in Ca2 +i induced by PIF was attenuated by both the phospholipase C inhibitor U73122 and 2-APB, an inhibitor of the inositol 1,4,5-triphosphate receptor, suggesting the involvement of a G-protein. ⺠Binding of the PIF to its receptor in skeletal muscle triggers a rise in Ca2 +i, which initiates a signalling cascade leading to a depression in protein synthesis, and an increase in protein degradation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 24, Issue 11, November 2012, Pages 2118-2122
Journal: Cellular Signalling - Volume 24, Issue 11, November 2012, Pages 2118-2122
نویسندگان
K.A. Mirza, M.J. Tisdale,