Tissue kallikrein protects neurons from hypoxia/reoxygenation-induced cell injury through Homer1b/c

► Homer1b/c has protective effects against OGD/R-induced neuronal injury. ► TK reduces cell injury induced by OGD/R through activating Homer1b/c. ► Homer1b/c-ERK1/2 and -Akt pathways are involved in the neuroprotection role of TK.