Lysophosphatidic acid activates TGFBIp expression in human corneal fibroblasts through a TGF-β1-dependent pathway

► LPA increases TGFBIp expression in human corneal fibroblasts. ► LPA induces TGFBIp expression by stimulating secretion of TGF-β1. ► Activation of JNK is involved in LPA-induced secretion of TGF-β1. ► Smad2/3 is involved in the LPA-induced TGFBIp expression. ► LPA-mediated activation of TGFBIp depends on LPA1 and autocrine secretion of TGF-β. ► LPA signaling may be used for the prevention of treatment for corneal diseases.