Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium

► Blocking of the AT1R reduces pathological neovascularization in the mouse retina. ► Ang II modulates VEGF-induced angiogenesis through opposing effects of AT1R and AT2R. ► The pro-angiogenic effect of the AT1R requires activation of G12/13 proteins. ► The angiostatic effect of the AT2R involves Gi proteins, Src and Ser/Thr-kinases. ► The regulation of endothelial cells by VEGF and Ang II converges on RhoA activity.