Downregulation of integrin-linked kinase inhibits epithelial-to-mesenchymal transition and metastasis in bladder cancer cells

► ILK siRNA inhibits phosphorylation level of downstream signaling target molecules. ► ILK siRNA affects the expression of proteins associated with EMT and metastasis. ► ILK siRNA influences cytoskeleton, cell morphology, proliferation and cell cycle. ► ILK siRNA is involved in cell migration, adhesion and invasion. ► ILK siRNA suppresses tumor growth and metastasis of bladder cancer cells.