کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10816422 | 1058572 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phosphorylation of the Retinoid X Receptor at the Omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Phosphorylation of the Retinoid X Receptor at the Omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity Phosphorylation of the Retinoid X Receptor at the Omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity](/preview/png/10816422.png)
چکیده انگلیسی
The retinoid response is mediated by two classes of nuclear receptors, the retinoic acid receptors (RARα, β, and γ) and the retinoid X receptors (RXRα, β, and γ) which act as ligand-dependent heterodimeric RAR/RXR transcription activators. Like most transcription factors, RARs and RXRs are regulated by phosphorylation processes. Here, we report that stress agents induce RXRα phosphorylation, subsequently to the activation of the stress-activated protein kinases cascade (JNKs). This phosphorylation process concerns three residues located in the N-terminal AF-1 domain of RXRα and one located in the omega loop of the Ligand Binding Domain. To decipher how stress-induced RXRα phosphorylation influences the transcription of RA-target genes, we used a ribotoxic stress agent, anisomycin, which activates signaling kinases without promoting DNA or protein damages, at subinhibitory concentrations. Taking advantage of vectors expressing recombinant RXRα mutated at its phosphorylation sites and of F9 cell lines re-expressing the same RXRα mutants in an RXRα null background, we provide evidence that stress signaling modulates RAR/RXRα-mediated transcription, through the phosphorylation of RXRα at the residue located in the Omega loop, in a promoter context-dependent manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 17, Issue 10, October 2005, Pages 1229-1239
Journal: Cellular Signalling - Volume 17, Issue 10, October 2005, Pages 1229-1239
نویسندگان
Nathalie Bruck, Julie Bastien, Gaétan Bour, Anne Tarrade, Jean-Luc Plassat, Annie Bauer, Sylvie Adam-Stitah, Cécile Rochette-Egly,