Proline-rich Akt substrate of 40Â kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway

► Proline-rich Akt substrate of 40 kDa (PRAS40) is a new substrate of Akt pathway. ► PRAS40 interacts with mTORC1 as both a substrate and an inhibitor of mTORC1. ► Phosphorylation of PRAS40 by Akt or mTORC1 raises the activity of mTORC1. ► This review summarizes the regulation/effects of PRAS40 relating to Akt/mTORC1.