Regulation of TGFβ receptor trafficking and signaling by atypical protein kinase C

► We assessed TGFß receptor trafficking and signalling in cells treated with PKC inhibitors. ► PKC inhibition reduces TGFß receptor trafficking and increases Smad2 phosphorylation. ► TGFß receptor ubiquitination increases with aPKC inhibition. ► siRNA towards aPKC increases Smad2 phosphorylation and reduces TGFß receptor degradation.